Heather, I'm a little confused. Did the med have no effect on his agitation or is it just because he didn't fall asleep like he has in the past that you think it wasn't working? My DH takes zyprexa but at a much lower dose and I believe his is taken at night. I put in this link to Medline Plus - www.nlm.nih.gov/medlinepl...ation.html - I have used it as a source to get info on new meds, etc - thought it might be of some help to you. Others may have more feedback that they can give you. Hope your son is doing better tonight. Let us know how you do.